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BACKGROUND: Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents. The molecular mechanism behind OS progression and metastasis remains poorly understood, which limits the effectiveness of current therapies. RNA N

METHODS: Liquid chromatography-tandem mass spectrometry (LC-MS/MS), dot blotting, and colorimetric ELISA were used to detect m

FINDINGS: We observed the abundance of m

INTERPRETATION: Our study revealed that METTL14 contributes to OS progression and ATRA resistance as an m

FUNDING: This work was supported by the National Natural Science Foundation of China (Grants 81972510 and 81772864).


Adolescent, Bone Neoplasms, Cell Line, Tumor, Chromatography, Liquid, Humans, Methyltransferases, Osteosarcoma, RNA, RNA, Messenger, RNA-Binding Proteins, Tandem Mass Spectrometry, Trans-Activators, Tretinoin, Tumor Suppressor Proteins



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