Positioning the Brainstem Within the Neural Network of Threat Prediction

Authors

Xu O Zhang
Fabricio H Do Monte

Publication Date

2-1-2023

Journal

Trends in Neuroscience

Abstract

In a recent study, Strickland and McDannald dissected the role of brainstem networks in threat prediction. Using probabilistic threat discrimination in rats, the authors demonstrated that brainstem neurons estimate threat probability and generate positive aversive prediction errors after unexpected outcomes. Their findings suggest that, beyond organizing defensive behaviors, brainstem neurons are involved in threat prediction computations.

Keywords

Rats, Animals, Brain Stem, Neurons, Neural Networks, Computer, Periaqueductal Gray

DOI

10.1016/j.tins.2022.11.004

PMID

36470706

PMCID

PMC9877175

PubMedCentral® Posted Date

February 2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes