Association of Cerebrovascular Stability Index and Head Circumference Between Infants With and Without Congenital Heart Disease

Authors

Nhu N Tran
Michelle Tran
Ashok Panigrahy
Ken M Brady
Jodie K Votava-Smith

Publication Date

10-1-2022

Journal

Pediatric Cardiology

Abstract

Congenital heart disease (CHD) is a common birth defect in the United States. CHD infants are more likely to have smaller head circumference and neurodevelopmental delays; however, the cause is unknown. Altered cerebrovascular hemodynamics may contribute to neurologic abnormalities, such as smaller head circumference, thus we created a novel Cerebrovascular Stability Index (CSI), as a surrogate for cerebral autoregulation. We hypothesized that CHD infants would have an association between CSI and head circumference. We performed a prospective, longitudinal study in CHD infants and healthy controls. We measured CSI and head circumference at 4 time points (newborn, 3, 6, 9 months). We calculated CSI by subtracting the average 2-min sitting from supine cerebral oxygenation (rcSO

Keywords

Congenital heart disease, Head circumference, Cerebrovascular Stability Index, Infants, Near infrared spectroscopy

DOI

10.1007/s00246-022-02891-3

PMID

35426499

PMCID

PMC10230613

PubMedCentral® Posted Date

May 2023

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes