Faculty, Staff and Student Publications
Publication Date
1-30-2025
Journal
Journal of Molecular Cell Biology
Abstract
Obesity per se is rapidly emerging all over the planet and further accounts for many other life-threatening conditions, such as diabetes, cardiovascular diseases, and cancers. Decreased oxygen supply or increased relative oxygen consumption in the adipose tissue results in adipose tissue hypoxia, which is a hallmark of obesity. This review aims to provide an up-to-date overview of the hypoxia signaling in the adipose tissue. First, we summarize literature evidence to demonstrate that hypoxia is regularly observed during adipose tissue remodeling in humans and rodent models with obesity. Next, we discuss how hypoxia-inducible factors (HIFs) are regulated and how adipose tissues behave in response to hypoxia. Then, the differential roles of adipose HIF-1α and HIF-2α in adipose tissue biology and obesity pathology are highlighted. Finally, the review emphasizes the importance of modulating adipose hypoxia as a therapeutic avenue to assist adipose tissues in functionally adapting to hypoxic conditions, ultimately promoting adipose health and improving outcomes due to obesity.
Keywords
Humans, Adipose Tissue, Animals, Signal Transduction, Obesity, Hypoxia, Hypoxia-Inducible Factor 1, alpha Subunit, Cell Hypoxia, Basic Helix-Loop-Helix Transcription Factors, hypoxia, obesity, adipose tissue, hypoxia-inducible factor
DOI
10.1093/jmcb/mjae039
PMID
39363240
PMCID
PMC11892559
PubMedCentral® Posted Date
10-3-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes