Faculty, Staff and Student Publications

Publication Date

1-1-2023

Journal

Frontiers in Oncology

Abstract

In osteosarcoma patients, metastasis of the primary cancer is the leading cause of death. At present, management options to prevent metastasis are limited and non-curative. In this study, we review the current state of knowledge on the molecular mechanisms of metastasis and discuss promising new therapies to combat osteosarcoma metastasis. Genomic and epigenomic changes, metabolic reprogramming, transcription factors, dysregulation of physiologic pathways, and alterations to the tumor microenvironment are some of the changes reportedly involved in the regulation of osteosarcoma metastasis. Key factors within the tumor microenvironment include infiltrating lymphocytes, macrophages, cancer-associated fibroblasts, platelets, and extracellular components such as vesicles, proteins, and other secreted molecules. We conclude by discussing potential osteosarcoma-limiting agents and their clinical studies.

Keywords

osteosarcoma, metastasis, reprogramming, tumor microenvironment, mechanism

DOI

10.3389/fonc.2023.1117867

PMID

37197432

PMCID

PMC10183593

PubMedCentral® Posted Date

5-1-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

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