Faculty, Staff and Student Publications
Publication Date
1-1-2023
Journal
Frontiers in Oncology
Abstract
In osteosarcoma patients, metastasis of the primary cancer is the leading cause of death. At present, management options to prevent metastasis are limited and non-curative. In this study, we review the current state of knowledge on the molecular mechanisms of metastasis and discuss promising new therapies to combat osteosarcoma metastasis. Genomic and epigenomic changes, metabolic reprogramming, transcription factors, dysregulation of physiologic pathways, and alterations to the tumor microenvironment are some of the changes reportedly involved in the regulation of osteosarcoma metastasis. Key factors within the tumor microenvironment include infiltrating lymphocytes, macrophages, cancer-associated fibroblasts, platelets, and extracellular components such as vesicles, proteins, and other secreted molecules. We conclude by discussing potential osteosarcoma-limiting agents and their clinical studies.
Keywords
osteosarcoma, metastasis, reprogramming, tumor microenvironment, mechanism
DOI
10.3389/fonc.2023.1117867
PMID
37197432
PMCID
PMC10183593
PubMedCentral® Posted Date
5-1-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes