Faculty, Staff and Student Publications
Publication Date
4-25-2024
Journal
Life
Abstract
Olfactory receptors (ORs) represent one of the largest yet least investigated families of G protein-coupled receptors in mammals. While initially believed to be functionally restricted to the detection and integration of odors at the olfactory epithelium, accumulating evidence points to a critical role for ectopically expressed ORs in the regulation of cellular homeostasis in extranasal tissues. This review aims to summarize the current state of knowledge on the expression and physiological functions of ectopic ORs in the cardiovascular system, kidneys, and primary metabolic organs and emphasizes how altered ectopic OR signaling in those tissues may impact cardiovascular-kidney-metabolic health.
Keywords
G protein-coupled receptor, cardiovascular, heart disease, kidney, metabolism, olfactory receptor
DOI
10.3390/life14050548
PMID
38792570
PMCID
PMC11122380
PubMedCentral® Posted Date
4-25-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes