Migraine and vasodepressor syncope in a large family.

Publication Date



Tex Heart Inst J. 2009; 36(5): 468–469.


We evaluated a 47-year-old woman for recurrent migraine and syncope. The patient had 7 children (not examined by the authors), all of whom also experienced migraine and syncope. The patient's father, now deceased, had reportedly experienced migraine and episodes of feeling faint. All 5 of the patient's siblings reported migraine, and 4 of the 5 reported syncope. The case of our patient, which we discuss herein, suggests a genetic link between these 2 conditions, both of which include vascular dysregulation in their pathogenesis. To our knowledge, the medical literature contains no previous description of familial associations of combined migraine and syncope.


Adolescent, Child, Child, Preschool, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Migraine Disorders, Pedigree, Recurrence, Risk Factors, Syncope, Vasovagal, Young Adult