Faculty, Staff and Student Publications

Publication Date

1-1-2023

Journal

Proceedings - Baylor University. Medical Center

Abstract

A man in his 60s presented with a gradual progressive right-sided neck mass. Initial core biopsy was inconclusive and he was treated with a short course of oral prednisone for presumed sarcoidosis. Two months later, the patient developed worsening dysphagia, hoarseness of voice, dyspnea, and weight loss. Physical examination revealed bilateral cervical and right axillary lymphadenopathy. A right axillary lymph node excisional biopsy was performed and immunohistochemistry was diffusely positive for OCT4, SALL4, CD117, PLAP, confirming the diagnosis of metastatic seminoma. He received three cycles of bleomycin, etoposide, and cisplatin; bleomycin was omitted for the fourth cycle due to concern for toxicity. Restaging scans after four cycles of chemotherapy showed a favorable response to therapy. Unfortunately, the patient died from bleomycin pulmonary toxicity. This case illustrates a rare and atypical presentation of metastatic seminoma in an elderly patient.

Keywords

Cervical lymphadenopathy, elderly men, metastatic seminoma

DOI

10.1080/08998280.2023.2167184

PMID

37091773

PMCID

PMC10120549

PubMedCentral® Posted Date

1-24-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

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