Faculty, Staff and Student Publications
Publication Date
6-1-2022
Journal
International Journal of STD & AIDS
Abstract
Background: Risk of anal squamous cell carcinoma (anal cancer) is greater among men who have sex with men (MSM) living with human immunodeficiency virus (HIV). We describe the frequency of and factors associated with abnormal anal cytology results in Colombian MSM living with HIV.
Methods: This retrospective observational cohort study included MSM ≥18 years old living with HIV screened with anal cytology at Hospital Universitario San Ignacio in Bogotá, Colombia between January 2019 and February 2020. A multivariable log-binomial regression model estimated associations with abnormal anal cytology.
Results: A total of 211 patients were included. Mean age was 35.6 years. Sixty-eight (32.3%) had an abnormal anal cytology result: ASC-US 33.8% (n = 23); LSIL 60.3% (n = 41); and HSIL 5.9% (n = 4). MSM with an STI diagnosis in the previous 12 months (RR 1.48, [95% CI 1.03-2.12], p = 0.032) or with a CD4+ T cell count < 200 (RR 2.08 [95% CI 1.16-3.73], p = 0.014) were significantly more likely to have abnormal anal cytology.
Conclusions: These data provide crucial information to guide scale up of anal cancer screening at select centers in Colombia. Our results also suggest STI prevention efforts and improved virological control among MSM living with HIV may have the secondary benefit of reducing the risk of anal cancer.
Keywords
Adolescent, Adult, Anal Canal, Anus Neoplasms, Colombia, HIV Infections, Homosexuality, Male, Hospitals, Humans, Male, Papillomavirus Infections, Retrospective Studies, Sexual and Gender Minorities, Anus neoplasms, human immunodeficiency virus, men who have sex with men, cancer screening
DOI
10.1177/09564624221097742
PMID
35491739
PMCID
PMC10430884
PubMedCentral® Posted Date
8-16-2023
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes