Anxiety Symptoms and Suicidal Thoughts and Behaviors Among Patients With Mood Disorders

Authors

Marsal Sanches
Linh K Nguyen
Tong Han Chung
Paul Nestadt
Holly C Wilcox
William H Coryell
Jair C Soares
Sudhakar Selvaraj

Publication Date

6-15-2022

Journal

Journal of Affective Disorders

Abstract

Background: Though the association between anxiety disorders and suicidal behavior is well-described, the impact of anxiety symptoms on suicidal thoughts and behaviors (STB) across different mood disorders is still unclear.

Methods: We performed a registry-based retrospective study utilizing outcome measure data collected by the National Network of Depression Centers (NNDC), a nationwide nonprofit consortium of 26 leading clinical and academic member centers in the United States. The sample consisted of 2607 outpatients with mood disorders (major depressive disorder or bipolar disorders). Demographic and clinical variables were compared based on the presence or absence of STB and severity of anxiety symptoms (minimal, mild, moderate, and severe). Univariate and multivariable logistic regressions were conducted to examine the correlations of STB, considering multicollinearity.

Results: Patients with mild, moderate, and severe anxiety symptoms had higher odds of STB than those with minimal symptoms. Gender, marital status, age, and depressive symptoms were other strong predictors of STB. There was no difference in the odds of STB between patients with major depressive disorder (MDD) and those with bipolar disorders (BD). However, the odds of suicidal ideation were slightly lower among patients with BD than those with MDD.

Limitations: Our sample was comprised only of outpatients, limiting the generalization of our findings. Other limitations include the lack of structured interviews for diagnostic characterization of the patients and the utilization of data on anxiety and mood obtained solely through self-report scales.

Conclusions: We found a cross-sectional association between the severity of anxiety symptoms and STB among patients with mood disorders. This study demonstrates the need for a suicide risk assessment in patients with mood disorders reporting anxiety symptoms.

Keywords

Anxiety, Cross-Sectional Studies, Depressive Disorder, Major, Humans, Mood Disorders, Retrospective Studies, Risk Factors, Suicidal Ideation

Comments

This article has been corrected. See J Affect Disord. 2022 Dec 23.

DOI

10.1016/j.jad.2022.03.046

PMID

35331824

PMCID

PMC9321173

PubMedCentral® Posted Date

6-15-2023

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes