Faculty, Staff and Student Publications
Publication Date
3-1-2024
Journal
Advanced Materials
Abstract
Carbon-based superoxide dismutase (SOD) mimetic nanozymes have recently been employed as promising antioxidant nanotherapeutics due to their distinct properties. The structural features responsible for the efficacy of these nanomaterials as antioxidants are, however, poorly understood. Here, the process-structure-property-performance properties of coconut-derived oxidized activated charcoal (cOAC) nano-SOD mimetics are studied by analyzing how modifications to the nanomaterial's synthesis impact the size, as well as the elemental and electrochemical properties of the particles. These properties are then correlated to the in vitro antioxidant bioactivity of poly(ethylene glycol)-functionalized cOACs (PEG-cOAC). Chemical oxidative treatment methods that afford smaller, more homogeneous cOAC nanoparticles with higher levels of quinone functionalization show enhanced protection against oxidative damage in bEnd.3 murine endothelioma cells. In an in vivo rat model of mild traumatic brain injury (mTBI) and oxidative vascular injury, PEG-cOACs restore cerebral perfusion rapidly to the same extent as the former nanotube-derived PEG-hydrophilic carbon clusters (PEG-HCCs) with a single intravenous injection. These findings provide a deeper understanding of how carbon nanozyme syntheses can be tailored for improved antioxidant bioactivity, and set the stage for translation of medical applications.
Keywords
Rats, Mice, Animals, Antioxidants, Charcoal, Carbon, Superoxide Dismutase, Brain Injuries, Traumatic, Chlorambucil, Oleic Acids, Oxidized activated charcoal, antioxidant, carbon nanotechnology, nanozyme, superoxide dismutase mimetic
DOI
10.1002/adma.202211239
PMID
36940058
PMCID
PMC10509328
PubMedCentral® Posted Date
3-1-2025
PubMedCentral® Full Text Version
Author MSS
Graphical Abstract
Published Open-Access
yes
Included in
Internal Medicine Commons, Medical Sciences Commons, Trauma Commons, Wounds and Injuries Commons