Faculty, Staff and Student Publications
Publication Date
10-3-2024
Journal
International Journal of Molecular Sciences
Abstract
Syntaxin 3 is a member of a large protein family of syntaxin proteins that mediate fusion between vesicles and their target membranes. Mutations in the ubiquitously expressed syntaxin 3A splice form give rise to a serious gastrointestinal disorder in humans called microvillus inclusion disorder, while mutations that additionally involve syntaxin 3B, a splice form that is expressed primarily in retinal photoreceptors and bipolar cells, additionally give rise to an early onset severe retinal dystrophy. In this review, we discuss recent studies elucidating the roles of syntaxin 3B and the regulation of syntaxin 3B functionality in membrane fusion and neurotransmitter release in the vertebrate retina.
Keywords
Humans, Qa-SNARE Proteins, Animals, Vision, Ocular, SNARE Proteins, Membrane Fusion, Mutation, syntaxin, stx3, retina, ribbon synapse, SNARE, retinal degeneration, exocytosis, membrane fusion, retinal dystrophy, syntaxin 3B
DOI
10.3390/ijms251910665
PMID
39408994
PMCID
PMC11476516
PubMedCentral® Posted Date
10-3-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes