Faculty, Staff and Student Publications

Publication Date

10-27-2024

Journal

Viruses

Abstract

COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with hypercoagulability and increased incidence of thrombotic events. In this study, we investigated the levels of neutrophil extracellular trap biomarkers and von Willebrand factor to assess if these could predict the occurrence of a thrombotic event in COVID-19 patients. We enrolled 202 patients hospitalized with symptomatic COVID-19 infection. Of those, 104 patients did not experience any type of thrombotic events before or during their hospitalization. These patients were compared to the other cohort of 98, who experienced thrombotic events before or during their hospitalization. In total, 61 patients who experienced thrombotic events had the event after initial blood collection, so the predictive capacity of biomarkers in these patients was evaluated. Citrullinated histone H3 was the best predictive biomarker for thrombotic events in COVID-19 regardless of age, sex, and race; disease severity was also a significant predictor in most thrombotic event groups. These results may better inform treatment and prophylaxis of thrombotic events in COVID-19 and similar viral illnesses in the future to improve outcomes and reduce mortality.

Keywords

Humans, COVID-19, Extracellular Traps, Male, Female, Thrombosis, Middle Aged, Biomarkers, SARS-CoV-2, Aged, Adult, Neutrophils, von Willebrand Factor, Blood Coagulation Disorders, Histones, coronavirus, COVID-19, thrombosis, viral infection, epidemiology, coagulation, neutrophil extracellular trap

DOI

10.3390/v16111677

PMID

39599792

PMCID

PMC11598969

PubMedCentral® Posted Date

10-27-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

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