Faculty, Staff and Student Publications
Publication Date
7-1-2022
Journal
Translational Oncology
Abstract
Purpose: Cancer patients with COVID-19 likely express biomarker changes in circulation. However, the biomarkers used in SARS-CoV-2 infected cancer patients for COVID-19 severity and prognosis are largely unclear. Therefore, this systematic review aims to determine what biomarkers were measured in cancer patients with COVID-19 and their prognostic utility.
Methods: A systematic literature review in PubMed, Embase, and Scopus was performed on June 16th, 2021. The search keywords coronavirus, neoplasm, biomarkers, and disease progression were used to filter out 17 eligible studies, which were then carefully evaluated.
Results: A total of 4,168 patients, 16 types of cancer, and 60 biomarkers were included. Seven up-regulated markers, including CRP, d-dimer, ferritin, IL-2R, IL-6, LDH, and PCT, were identified in eligible studies. Albumin and hemoglobin were significantly down-regulated in cancer patients with COVID-19. Moreover, we observed that the SARS-CoV-2 infected cancer patients with lower CRP, ferritin, and LDH levels successfully survived from COVID-19 treatments.
Conclusion: Several important clinical biomarkers, such as CRP, ferritin, and LDH, may serve as the prognostic markers to predict the outcomes following COVID-19 treatment and monitor the deterioration of COVID-19 in cancer patients.
Keywords
SARS-CoV-2, COVID-19, Cancer, Prognostic biomarkers, Immunotherapy
DOI
10.1016/j.tranon.2022.101443
PMID
35523009
PMCID
PMC9057983
PubMedCentral® Posted Date
5-2-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Internal Medicine Commons, Medical Sciences Commons, Translational Medical Research Commons