Faculty, Staff and Student Publications
Publication Date
5-1-2024
Journal
Movement Disorders Clinical Practice
Abstract
Background: Although Huntington's disease (HD) is usually thought of as a triad of motor, cognitive, and psychiatric symptoms, there is growing appreciation of HD as a systemic illness affecting the entire body.
Objectives: This review aims to draw attention to these systemic non-motor symptoms in HD.
Methods: We identified relevant studies published in English by searching MEDLINE (from 1966 to September 2023), using the following subject headings: Huntington disease, autonomic, systemic, cardiovascular, respiratory, gastrointestinal, urinary, sexual and cutaneous, and additional specific symptoms.
Results: Data from 123 articles were critically reviewed with focus on systemic features associated with HD, such as cardiovascular, respiratory, gastrointestinal, urinary, sexual and sweating.
Conclusion: This systematic review draws attention to a variety of systemic and autonomic co-morbidities in patients with HD. Not all of them correlate with the severity of the primary HD symptoms or CAG repeats. More research is needed to better understand the pathophysiology and treatment of systemic and autonomic dysfunction in HD.
Keywords
Huntington Disease, Humans, Autonomic Nervous System Diseases, Cardiovascular Diseases, Gastrointestinal Diseases, autonomic, cardiovascular, respiratory, gastric, intestinal, urinary, sexual, sweating, thermoregulatory
DOI
10.1002/mdc3.14029
PMID
38529740
PMCID
PMC11078495
PubMedCentral® Posted Date
3-26-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes