Faculty, Staff and Student Publications
Publication Date
2-1-2025
Journal
Experimental Neurology
Abstract
Arginine modification can be a "switch" to regulate DNA transcription and a post-translational modification via methylation of a variety of cellular targets involved in signal transduction, gene transcription, DNA repair, and mRNA alterations. This consequently can turn downstream biological effectors "on" and "off". Arginine methylation is catalyzed by protein arginine methyltransferases (PRMTs 1-9) in both the nucleus and cytoplasm, and is thought to be involved in many disease processes. However, PRMTs have not been well-documented in the brain and their function as it relates to metabolism, circulation, functional learning and memory are understudied. In this review, we provide a comprehensive overview of PRMTs relevant to cellular stress, and future directions into PRMTs as therapeutic regulators in brain pathologies.
Keywords
Humans, Protein-Arginine N-Methyltransferases, Animals, Stress, Physiological, Arginine, Brain, Methylation, Cellular stress, Protein arginine methyltransferases, Brain injury, Neuroinflammation, Transcription factors
DOI
10.1016/j.expneurol.2024.115060
PMID
39551462
PMCID
PMC11973959
PubMedCentral® Posted Date
4-7-2025
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes