Faculty, Staff and Student Publications
Publication Date
6-28-2022
Journal
Cell Reports
Abstract
Image- and non-image-forming vision are essential for animal behavior. Here we use genetically modified mouse lines to examine retinal circuits driving image- and non-image-functions. We describe the outer retinal circuits underlying the pupillary light response (PLR) and circadian photoentrainment, two non-image-forming behaviors. Rods and cones signal light increments and decrements through the ON and OFF pathways, respectively. We find that the OFF pathway drives image-forming vision but cannot drive circadian photoentrainment or the PLR. Cone light responses drive image formation but fail to drive the PLR. At photopic levels, rods use the primary and secondary rod pathways to drive the PLR, whereas at the scotopic and mesopic levels, rods use the primary pathway to drive the PLR, and the secondary pathway is insufficient. Circuit dynamics allow rod ON pathways to drive two non-image-forming behaviors across a wide range of light intensities, whereas the OFF pathway is potentially restricted to image formation.
Keywords
Animals, Circadian Rhythm, Mice, Retina, Retinal Cone Photoreceptor Cells, Retinal Ganglion Cells, Rod Opsins
DOI
10.1016/j.celrep.2022.111003
PMID
35767957
PMCID
PMC9400924
PubMedCentral® Posted Date
8-24-2022
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes