Faculty, Staff and Student Publications
Publication Date
7-20-2024
Journal
Scientific Reports
Abstract
The aim of this study was to assess the profile of nasal microbiome and evaluate the effect of a specific nasal decolonization solution on the microbiome. We conducted a randomized, placebo-controlled, and parallel-group clinical study of 50 volunteers aged 18 years and older. The subjects were randomly assigned to receive a nasal antiseptic solution, containing povidone-iodine as the main ingredient, (n = 25) or a control solution (n = 25). Nasal swabs were obtained before application (baseline) and at 3 timepoints after application (5 min, 2 h, 24 h). Nasal swabs were subjected to next generation sequencing analysis and cultured in agar plates. At baseline, there were substantial associations between anaerobic species, Corynebacterium spp., Staphylococcus spp., and Dolosigranulum spp. Then, a high bioburden reduction was observed after the application of povidone-iodine (log
Keywords
Humans, Povidone-Iodine, Anti-Infective Agents, Local, Microbiota, Male, Female, Adult, Prospective Studies, Middle Aged, Nose, Young Adult, Bacteria, Administration, Intranasal, Corynebacterium
DOI
10.1038/s41598-023-46792-8
PMID
39033201
PMCID
PMC11271270
PubMedCentral® Posted Date
7-20-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes