Synchronous Clear Cell Renal Cell Carcinoma and Classic Hodgkin Lymphoma

Authors

Phuoc Christie-Nguyen
Ahmed A Ahmed
Nourhan Ibrahim
Jacob Armstrong
Brenda Mai

Publication Date

5-1-2025

Journal

IJU Case Reports

Abstract

Introduction: The coexistence of renal cell carcinoma and classic Hodgkin lymphoma is exceedingly rare, with only two documented cases. Here, we present the third case diagnosed in our institution.

Case presentation: A 46-year-old man presented with right flank pain, fever, mild pancytopenia, and renal mass on computed tomography scan, suggesting renal malignancy. Despite intravenous antibiotics and extensive workup for recurrent fever, his condition did not improve. A bone marrow biopsy revealed rare large EBV-positive B cells. Surprisingly, imaging only showed minimal intraabdominal lymphadenopathy in the perinephric region. Subsequent surgery confirmed clear cell renal cell carcinoma in the kidney and scattered large, atypical cells consistent with classic Hodgkin lymphoma in the suprahilar lymph node.

Conclusion: This case presents a rare case of classic Hodgkin lymphoma occurring in the perirenal region. When clinicians encounter unexplained symptoms in patients with primary tumors, additional biopsies should be considered for possible secondary malignancy.

Keywords

classic Hodgkin lymphoma, clear cell renal cell carcinoma, kidney neoplasms

DOI

10.1002/iju5.12831

PMID

40336730

PMCID

PMC12055214

PubMedCentral® Posted Date

2-13-2025

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes