Faculty, Staff and Student Publications
Publication Date
5-1-2025
Journal
Molecular Psychiatry
Abstract
Neuroimaging-based subtyping is increasingly used to explain heterogeneity in psychiatric disorders. However, the clinical utility of these subtyping efforts remains unclear, and replication has been challenging. Here we examined how the choice of neuroimaging measures influences the derivation of neuro-subtypes and the consequences for clinical delineation. On a clinically heterogeneous dataset (total n = 566) that included controls (n = 268) and cases (n = 298) of psychiatric conditions, including individuals diagnosed with post-traumatic stress disorder (PTSD), traumatic brain injury (TBI), and comorbidity of both (PTSD&TBI), we identified neuro-subtypes among the cases using either structural, resting-state, or task-based measures. The neuro-subtypes for each modality had high internal validity but did not significantly differ in their clinical and cognitive profiles. We further show that the choice of neuroimaging measures for subtyping substantially impacts the identification of neuro-subtypes, leading to low concordance across subtyping solutions. Similar variability in neuro-subtyping was found in an independent dataset (n = 1642) comprised of major depression disorder (MDD, n = 848) and controls (n = 794). Our results suggest that the highly anticipated relationships between neuro-subtypes and clinical features may be difficult to discover.
Keywords
Humans, Male, Neuroimaging, Female, Adult, Depressive Disorder, Major, Biomarkers, Middle Aged, Stress Disorders, Post-Traumatic, Brain Injuries, Traumatic, Brain, Mental Disorders, Magnetic Resonance Imaging
DOI
10.1038/s41380-024-02807-y
PMID
39511450
PMCID
PMC12015113
PubMedCentral® Posted Date
5-25-2025
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Medical Sciences Commons, Mental and Social Health Commons, Psychiatry Commons, Psychiatry and Psychology Commons