Faculty, Staff and Student Publications
Publication Date
3-1-2023
Journal
The Journal of Trauma and Acute Care Surgery
Abstract
Venous thromboembolism (VTE) is a major issue in trauma patients. Without prophylaxis, the rate of deep venous thrombosis approaches 60% and even with chemoprophylaxis may be nearly 30%. Advances in VTE reduction are imperative to reduce the burden of this issue in the trauma population. Novel approaches in VTE prevention may include new medications, dosing regimens, and extending prophylaxis to the postdischarge phase of care. Standard dosing regimens of low-molecular-weight heparin are insufficient in trauma, shifting our focus toward alternative dosing strategies to improve prophylaxis. Mixed data suggest that anti-Xa-guided dosage, weight-based dosing, and thromboelastography are among these potential strategies. The concern for VTE in trauma does not end upon discharge, however. The risk for VTE in this population extends well beyond hospitalization. Variable extended thromboprophylaxis regimens using aspirin, low-molecular-weight heparin, and direct oral anticoagulants have been suggested to mitigate this prolonged VTE risk, but the ideal approach for outpatient VTE prevention is still unclear. As part of the 2022 Consensus Conference to Implement Optimal Venous Thromboembolism Prophylaxis in Trauma, a multidisciplinary array of participants, including physicians from multiple specialties, pharmacists, nurses, advanced practice providers, and patients met to attack these issues. This paper aims to review the current literature on novel approaches for optimizing VTE prevention in injured patients and identify research gaps that should be investigated to improve VTE rates in trauma.
Keywords
Humans, Aftercare, Anticoagulants, Heparin, Low-Molecular-Weight, Patient Discharge, Venous Thromboembolism, Venous thromboembolism, thromboprophylaxis, low molecular weight heparin, unfractionated heparin, trauma
DOI
10.1097/TA.0000000000003854
PMID
36729884
PMCID
PMC9975027
PubMedCentral® Posted Date
3-1-2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes