Faculty, Staff and Student Publications
Publication Date
2-1-2024
Journal
Ethnicity & Disease
Abstract
Intracranial volume (ICV) reflects maximal brain development and is associated with later-life cognitive abilities. We quantified ICV among first- and second-generation Hispanic and Latino adults from the Study of Latinos-Investigation of Cognitive Aging - MRI (SOL-INCA-MRI), estimated ICV heritability, and tested its associations with previously reported genetic variants, both individually and as a genetic risk score (GRS). We also estimated the association of ICV with early life environmental measures: nativity or age of immigration and parental education. The estimated heritability of ICV was 19% (95% CI, 0.1%-56%) in n=1781 unrelated SOL-INCA-MRI individuals. Four of 10 tested genetic variants were associated with ICV and an increase of 1 SD of the ICV-GRS was associated with an increase of 10.37 cm
Keywords
Adult, Aged, Child, Female, Humans, Male, Middle Aged, Brain, Hispanic or Latino, Magnetic Resonance Imaging, Organ Size, United States, Adolescent, Young Adult, Hispanic or Latino, Genetic Associations, Heritability, Early Life Development
DOI
10.18865/ed.34.2.103
PMID
38973806
PMCID
PMC11223032
PubMedCentral® Posted Date
7-2-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes