Protein SUMOylation and Phase Separation: Partners in Stress?

Authors

Xiaodong Cheng

Publication Date

5-1-2023

Journal

Trends in Biochemical Sciences

Abstract

Protein SUMOylation is one of the most prevalent post-translational modifications (PTMs) and important for maintaining cellular homeostasis in response to various cellular stresses. Emerging evidence reveals the role of liquid-liquid phase separation (LLPS)/biomolecular condensates in cellular SUMOylation, potentially solving a puzzle regarding the cellular mechanism of SUMOylation regulation.

Keywords

Sumoylation, Protein Processing, Post-Translational, SUMOylation, biomolecular condensate, liquid-liquid phase separation, Stress response, multivalent interaction

DOI

10.1016/j.tibs.2022.12.003

PMID

36621339

PMCID

PMC10658744

PubMedCentral® Posted Date

11-20-2023

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes