Student and Faculty Publications

Authors

Jianxin Shi
Kouya Shiraishi
Jiyeon Choi
Keitaro Matsuo
Tzu-Yu Chen
Juncheng Dai
Rayjean J Hung
Kexin Chen
Xiao-Ou Shu
Young Tae Kim
Maria Teresa Landi
Dongxin Lin
Wei Zheng
Zhihua Yin
Baosen Zhou
Bao Song
Jiucun Wang
Wei Jie Seow
Lei Song
I-Shou Chang
Wei Hu
Li-Hsin Chien
Qiuyin Cai
Yun-Chul Hong
Hee Nam Kim
Yi-Long Wu
Maria Pik Wong
Brian Douglas Richardson
Karen M Funderburk
Shilan Li
Tongwu Zhang
Charles Breeze
Zhaoming Wang
Batel Blechter
Bryan A Bassig
Jin Hee Kim
Demetrius Albanes
Jason Y Y Wong
Min-Ho Shin
Lap Ping Chung
Yang Yang
She-Juan An
Hong Zheng
Yasushi Yatabe
Xu-Chao Zhang
Young-Chul Kim
Neil E Caporaso
Jiang Chang
James Chung Man Ho
Michiaki Kubo
Yataro Daigo
Minsun Song
Yukihide Momozawa
Yoichiro Kamatani
Masashi Kobayashi
Kenichi Okubo
Takayuki Honda
Dean H Hosgood
Hideo Kunitoh
Harsh Patel
Shun-Ichi Watanabe
Yohei Miyagi
Haruhiko Nakayama
Shingo Matsumoto
Hidehito Horinouchi
Masahiro Tsuboi
Ryuji Hamamoto
Koichi Goto
Yuichiro Ohe
Atsushi Takahashi
Akiteru Goto
Yoshihiro Minamiya
Megumi Hara
Yuichiro Nishida
Kenji Takeuchi
Kenji Wakai
Koichi Matsuda
Yoshinori Murakami
Kimihiro Shimizu
Hiroyuki Suzuki
Motonobu Saito
Yoichi Ohtaki
Kazumi Tanaka
Tangchun Wu
Fusheng Wei
Hongji Dai
Mitchell J Machiela
Jian Su
Yeul Hong Kim
In-Jae Oh
Victor Ho Fun Lee
Gee-Chen Chang
Ying-Huang Tsai
Kuan-Yu Chen
Ming-Shyan Huang
Wu-Chou Su
Yuh-Min Chen
Adeline Seow
Jae Yong Park
Sun-Seog Kweon
Kun-Chieh Chen
Yu-Tang Gao
Biyun Qian
Chen Wu
Daru Lu
Jianjun Liu
Ann G Schwartz
Richard Houlston
Margaret R Spitz
Ivan P Gorlov
Xifeng Wu
Ping Yang
Stephen Lam
Adonina Tardon
Chu Chen
Stig E Bojesen
Mattias Johansson
Angela Risch
Heike Bickeböller
Bu-Tian Ji
H-Erich Wichmann
David C Christiani
Gadi Rennert
Susanne Arnold
Paul Brennan
James McKay
John K Field
Sanjay S Shete
Loic Le Marchand
Geoffrey Liu
Angeline Andrew
Lambertus A Kiemeney
Shan Zienolddiny-Narui
Kjell Grankvist
Mikael Johansson
Angela Cox
Fiona Taylor
Jian-Min Yuan
Philip Lazarus
Matthew B Schabath
Melinda C Aldrich
Hyo-Sung Jeon
Shih Sheng Jiang
Jae Sook Sung
Chung-Hsing Chen
Chin-Fu Hsiao
Yoo Jin Jung
Huan Guo
Zhibin Hu
Laurie Burdett
Meredith Yeager
Amy Hutchinson
Belynda Hicks
Jia Liu
Bin Zhu
Sonja I Berndt
Wei Wu
Junwen Wang
Yuqing Li
Jin Eun Choi
Kyong Hwa Park
Sook Whan Sung
Li Liu
Chang Hyun Kang
Wen-Chang Wang
Jun Xu
Peng Guan
Wen Tan
Chong-Jen Yu
Gong Yang
Alan Dart Loon Sihoe
Ying Chen
Yi Young Choi
Jun Suk Kim
Ho-Il Yoon
In Kyu Park
Ping Xu
Qincheng He
Chih-Liang Wang
Hsiao-Han Hung
Roel C H Vermeulen
Iona Cheng
Junjie Wu
Wei-Yen Lim
Fang-Yu Tsai
John K C Chan
Jihua Li
Hongyan Chen
Hsien-Chih Lin
Li Jin
Jie Liu
Norie Sawada
Taiki Yamaji
Kathleen Wyatt
Shengchao A Li
Hongxia Ma
Meng Zhu
Zhehai Wang
Sensen Cheng
Xuelian Li
Yangwu Ren
Ann Chao
Motoki Iwasaki
Junjie Zhu
Gening Jiang
Ke Fei
Guoping Wu
Chih-Yi Chen
Chien-Jen Chen
Pan-Chyr Yang
Jinming Yu
Victoria L Stevens
Joseph F Fraumeni
Nilanjan Chatterjee
Olga Y Gorlova
Chao Agnes Hsiung
Christopher I Amos
Hongbing Shen
Stephen J Chanock
Nathaniel Rothman
Takashi Kohno
Qing Lan

Publication Date

5-26-2023

Journal

Nature Communications

Abstract

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.

Keywords

Humans, Genome-Wide Association Study, Genetic Predisposition to Disease, Adenocarcinoma of Lung, Asia, Eastern, Lung Neoplasms, Polymorphism, Single Nucleotide

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