Faculty, Staff and Student Publications
Publication Date
1-1-2025
Journal
Cancer Research Communications
Abstract
This study shows that populations of CAFs have distinct effects on pancreatic cancer progression and shows that depletion of CAFs expressing adipose markers potentiates tumor/metastasis suppression effects of immune checkpoint blockade.
Keywords
Pancreatic Neoplasms, Cancer-Associated Fibroblasts, Humans, Immunotherapy, Animals, Mice, Adipose Tissue, Tumor Microenvironment, Immune Checkpoint Inhibitors, Cell Line, Tumor, Stromal Cells
DOI
10.1158/2767-9764.CRC-24-0298
PMID
39620946
PMCID
PMC11694247
PubMedCentral® Posted Date
1-2-2025
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Bioinformatics Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Biomedical Informatics Commons, Data Science Commons, Immunotherapy Commons, Oncology Commons