
Faculty, Staff and Student Publications
Publication Date
1-1-2022
Journal
The Journal of Cardiovascular Aging
Abstract
INTRODUCTION: Aging is associated with cardiac myocyte loss, sarcopenia, and cardiac dysfunction. Adult cardiac myocytes are postmitotic cells with an insufficient proliferative capacity to compensate for myocyte loss. The canonical WNT (cWNT) pathway is involved in the regulation of cell cycle reentry in various cell types. The effects of the cWNT pathway on the expression of genes involved in cell cycle reentry in the postmitotic cardiac myocytes are unknown.
AIM: The aim of the study was to identify genes whose expression is regulated by the β-catenin, the indispensable component to the cWNT signaling, in the postmitotic myocytes.
METHODS AND RESULTS: Cardiac myocyte-specific tamoxifen-inducible MerCreMer (
CONCLUSION: Activation of the β-catenin of the cWNT pathway in postmitotic myocytes leads to cell cycle reentry and expression of genes involved in cytokinesis without leading to an increase in the number of myocytes. In contrast, suppression of the β-catenin modestly increases the expression of genes involved in oxidative phosphorylation. The findings provide insights into the role of β-catenin of the cWNT pathway in the regulation of cell cycle reentry and oxidative phosphorylation in the postmitotic cardiac myocytes.
Keywords
Myocyte proliferation, WNT signaling, beta-catenin, cytokinesis, cell cycle, oxidative phosphorylation, mitochondria
DOI
10.20517/jca.2021.35
PMID
35224561
PMCID
PMC8874274
PubMedCentral® Posted Date
2-25-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Cardiology Commons, Cardiovascular Diseases Commons, Medical Sciences Commons