Optimizing Electrode Configurations for EEG Mild Cognitive Impairment Detection

Authors

Yi Jiang
Xin Zhang
Zhiwei Guo
Xiaobo Zhou
Jiayuan He
Ning Jiang

Publication Date

1-2-2025

Journal

Scientific Reports

Abstract

The Optimal electrode configuration of Electroencephalograms (EEG) systems for mild cognitive impairment (MCI) detection and monitoring in non-clinical settings, i.e. number of electrodes and the positions of the electrodes, remains to be explored. In the current study, we explored the optimization of electrode configuration for MCI detection. We used a 32-channel EEG device to record the data of 21 MCI patients and 20 cognitively normal elderly (NC) undergoing working memory (WM) tasks. Based on the differential value (MCI group vs. NC group) from the Power Spectral Density (PSD) value of each electrode in θ and α frequency band during WM coding stage, six different electrode configurations were obtained: (1) four electrodes in the occipital lobe (OCL4); (2) three electrodes in the prefrontal lobe (PRL3); (3) four electrodes in the parietal lobe (PLL4), (4) eight electrodes in occipital combined parietal lobe (OPL8), (5) seven electrodes in occipital combined prefrontal lobe (OPL7); and (6) seven electrodes in parietal combined prefrontal lobe (PPL7). A multi-parameter combination-assisted binary logistic regression model was established to distinguish two groups. Receiver operating characteristic (ROC) curves were used to evaluate the MCI diagnostic power of each electrode configuration. The area under curve (AUC) of the ROC of electrode configurations OCL4, PRL3, PLL4, OPL8, OPL7 and PPL7 were 0.765, 0.683, 0.729, 0.83, 0.788, and 0.769, respectively. And the sensitivity of six electrode configurations were 0.962, 0.794, 0.873, 0.943, 0.859, and 0.938, respectively. Among these six configurations, OCL4, i.e. PO3, PO4, PO8, and PO7, had the highest sensitivity 96.2%, which meant that relying solely on these four electrodes of the occipital lobe had the potential to serve as an objective tool for preliminary screening of MCI. The abnormal brain rhythm characteristics of the frontal, parietal, and occipital lobes in the memory encoding stage of MCI provide a new perspective for MCI-WM impairment, which has the potential to be a novel biomarker for the early detection of pathological age-related cognitive decline. Further, a potential four-electrode configuration may be used for a novel detecting and monitoring EEG system of MCI in non-clinical settings.

Keywords

Humans, Cognitive Dysfunction, Electroencephalography, Female, Aged, Male, Electrodes, ROC Curve, Memory, Short-Term, Middle Aged, Aged, 80 and over, Mild cognitive impairment, Electroencephalography, Wearable EEG device, Working memory, Computational biology and bioinformatics, Neuroscience, Neurology

DOI

10.1038/s41598-024-84277-4

PMID

39748067

PMCID

PMC11696624

PubMedCentral® Posted Date

1-2-2025

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes