Date of Award

Spring 5-2020

Degree Name

Master of Science (MS)

Advisor(s)

MARCIA C DE OLIVEIRA OTTO PHD FAHA

Second Advisor

HARVEY LEVIN PHD ABPP-CN

Third Advisor

JOSE-MIGUEL YAMAL PHD

Abstract

Depending on a brain injury patient to accurately report their duration of unconsciousness and amnesia is clearly flawed. We constructed biomarker-based models to validate these self-reported measurements using a GCS 13-15 subset of participants from TRACK-TBI, a multi-institutional study on traumatic brain injury. Potential covariates were assessed for significant interactions with biomarker level. We report that the predictions of LOC and PTA failed. GFAP exhibited the most consistent serum level increase between categories of both LOC and PTA. Given a number of issues with the study sample, we recommend continued investigation on the prediction of LOC and PTA using a larger database.

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