Faculty, Staff and Student Publications
Publication Date
10-1-2023
Journal
Medicine & Science in Sports & Exercise
Abstract
PURPOSE: The aim of this study was to understand the serum metabolomic signatures of moderate-to-vigorous physical activity (MVPA) and sedentary behavior, and further associate their metabolomic signatures with incident cardiometabolic diseases.
METHODS: This analysis included 2711 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) aged 18-74 yr (2008-2011). An untargeted, liquid chromatography-mass spectrometry was used to profile the serum metabolome. The associations of metabolites with accelerometer-measured MVPA and sedentary time were examined using survey linear regressions adjusting for covariates. The weighted correlation network analysis identified modules of correlated metabolites in relation to sedentary time, and the modules were associated with incident diabetes, dyslipidemia, and hypertension over the 6-yr follow-up.
RESULTS: Of 624 metabolites, 5 and 102 were associated with MVPA and sedentary behavior at false discovery rate (FDR)
CONCLUSIONS: In this study of US Hispanics/Latinos, we identified multiple serum metabolomic signatures of sedentary behavior and their associations with risk of incident diabetes, hypertension, and dyslipidemia. These findings suggest a potential role of circulating metabolites in the links between sedentary behavior and cardiometabolic diseases.
Keywords
Humans, Cardiovascular Diseases, Diabetes Mellitus, Glycerol, Hispanic or Latino, Hypertension, Metabolome, Plasmalogens, Risk Factors, Sedentary Behavior, Adolescent, Young Adult, Adult, Middle Aged, Aged, accelerometer, mvpa, sedentary behavior, serum metabolomics
DOI
10.1249/MSS.0000000000003205
PMID
37170952
PMCID
PMC10523950
PubMedCentral® Posted Date
10-1-2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Endocrine System Diseases Commons, Endocrinology, Diabetes, and Metabolism Commons, Public Health Commons