Faculty, Staff and Student Publications
Publication Date
1-31-2023
Journal
Communications Biology
Abstract
Sleep Disordered Breathing (SDB) is a common disease associated with increased risk for cardiometabolic, cardiovascular, and cognitive diseases. How SDB affects the molecular environment is still poorly understood. We study the association of three SDB measures with gene expression measured using RNA-seq in multiple blood tissues from the Multi-Ethnic Study of Atherosclerosis. We develop genetic instrumental variables for the associated transcripts as polygenic risk scores (tPRS), then generalize and validate the tPRS in the Women's Health Initiative. We measure the associations of the validated tPRS with SDB and serum metabolites in Hispanic Community Health Study/Study of Latinos. Here we find differential gene expression by blood cell type in relation to SDB traits and link P2XR4 expression to average oxyhemoglobin saturation during sleep and butyrylcarnitine (C4) levels. These findings can be used to develop interventions to alleviate the effect of SDB on the human molecular environment.
Keywords
Humans, Hispanic or Latino, Multiomics, Sleep, Sleep Apnea Syndromes, Oxyhemoglobins, Receptors, Purinergic P2X7, Multifactorial Inheritance, Epidemiology, Genetics research, Data integration
DOI
10.1038/s42003-023-04520-y
PMID
36721044
PMCID
PMC9889381
PubMedCentral® Posted Date
1-31-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes