Faculty, Staff and Student Publications

Publication Date

1-1-2023

Journal

Gut Microbes

Abstract

BACKGROUND: The gut microbiome is altered in chronic kidney disease (CKD), potentially contributing to CKD progression and co-morbidities, but population-based studies of the gut microbiome across a wide range of kidney function and damage are lacking.

METHODS: In the Hispanic Community Health Study/Study of Latinos, gut microbiome was assessed by shotgun sequencing of stool (

RESULTS: Higher eGFR was associated with overall gut microbiome composition, greater abundance of species from Prevotella, Faecalibacterium, Roseburia, and Eubacterium, and microbial functions related to synthesis of long-chain fatty acids and carbamoyl-phosphate. Higher UAC ratio and CKD were related to lower gut microbiome diversity and altered overall microbiome composition only in participants without diabetes. Microbiome features related to better kidney health were associated with many serum metabolites (e.g., higher indolepropionate, beta-cryptoxanthin; lower imidazole propionate, deoxycholic acids, p-cresol glucuronide). Imidazole propionate, deoxycholic acid metabolites, and p-cresol glucuronide were associated with prospective reductions in eGFR and/or increases in UAC ratio over ~6 y.

CONCLUSIONS: Kidney function is a significant correlate of the gut microbiome, while the relationship of kidney damage with the gut microbiome depends on diabetes status. Gut microbiome metabolites may contribute to CKD progression.

Keywords

Humans, Cross-Sectional Studies, Gastrointestinal Microbiome, Hispanic or Latino, Kidney, Public Health, Renal Insufficiency, Chronic, Gut microbiome, chronic kidney disease, glomerular filtration rate, metabolites

DOI

10.1080/19490976.2023.2186685

PMID

36882941

PMCID

PMC10012940

PubMedCentral® Posted Date

3-7-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

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