Faculty, Staff and Student Publications
Publication Date
1-1-2023
Journal
Gut Microbes
Abstract
BACKGROUND: The gut microbiome is altered in chronic kidney disease (CKD), potentially contributing to CKD progression and co-morbidities, but population-based studies of the gut microbiome across a wide range of kidney function and damage are lacking.
METHODS: In the Hispanic Community Health Study/Study of Latinos, gut microbiome was assessed by shotgun sequencing of stool (
RESULTS: Higher eGFR was associated with overall gut microbiome composition, greater abundance of species from Prevotella, Faecalibacterium, Roseburia, and Eubacterium, and microbial functions related to synthesis of long-chain fatty acids and carbamoyl-phosphate. Higher UAC ratio and CKD were related to lower gut microbiome diversity and altered overall microbiome composition only in participants without diabetes. Microbiome features related to better kidney health were associated with many serum metabolites (e.g., higher indolepropionate, beta-cryptoxanthin; lower imidazole propionate, deoxycholic acids, p-cresol glucuronide). Imidazole propionate, deoxycholic acid metabolites, and p-cresol glucuronide were associated with prospective reductions in eGFR and/or increases in UAC ratio over ~6 y.
CONCLUSIONS: Kidney function is a significant correlate of the gut microbiome, while the relationship of kidney damage with the gut microbiome depends on diabetes status. Gut microbiome metabolites may contribute to CKD progression.
Keywords
Humans, Cross-Sectional Studies, Gastrointestinal Microbiome, Hispanic or Latino, Kidney, Public Health, Renal Insufficiency, Chronic, Gut microbiome, chronic kidney disease, glomerular filtration rate, metabolites
DOI
10.1080/19490976.2023.2186685
PMID
36882941
PMCID
PMC10012940
PubMedCentral® Posted Date
3-7-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Digestive System Diseases Commons, Gastroenterology Commons, Nephrology Commons, Public Health Commons, Race and Ethnicity Commons