Journal Articles

Authors

Céline Bellenguez
Fahri Küçükali
Iris E Jansen
Luca Kleineidam
Sonia Moreno-Grau
Najaf Amin
Adam C Naj
Rafael Campos-Martin
Benjamin Grenier-Boley
Victor Andrade
Peter A Holmans
Anne Boland
Vincent Damotte
Sven J van der Lee
Marcos R Costa
Teemu Kuulasmaa
Qiong Yang
Itziar de Rojas
Joshua C Bis
Amber Yaqub
Ivana Prokic
Julien Chapuis
Shahzad Ahmad
Vilmantas Giedraitis
Dag Aarsland
Pablo Garcia-Gonzalez
Carla Abdelnour
Emilio Alarcón-Martín
Daniel Alcolea
Montserrat Alegret
Ignacio Alvarez
Victoria Álvarez
Nicola J Armstrong
Anthoula Tsolaki
Carmen Antúnez
Ildebrando Appollonio
Marina Arcaro
Silvana Archetti
Alfonso Arias Pastor
Beatrice Arosio
Lavinia Athanasiu
Henri Bailly
Nerisa Banaj
Miquel Baquero
Sandra Barral
Alexa Beiser
Ana Belén Pastor
Jennifer E Below
Penelope Benchek
Luisa Benussi
Claudine Berr
Céline Besse
Valentina Bessi
Giuliano Binetti
Alessandra Bizarro
Rafael Blesa
Mercè Boada
Eric Boerwinkle
Barbara Borroni
Silvia Boschi
Paola Bossù
Geir Bråthen
Jan Bressler
Catherine Bresner
Henry Brodaty
Keeley J Brookes
Luis Ignacio Brusco
Dolores Buiza-Rueda
Katharina Bûrger
Vanessa Burholt
William S Bush
Miguel Calero
Laura B Cantwell
Geneviève Chene
Jaeyoon Chung
Michael L Cuccaro
Ángel Carracedo
Roberta Cecchetti
Laura Cervera-Carles
Camille Charbonnier
Hung-Hsin Chen
Caterina Chillotti
Simona Ciccone
Jurgen A H R Claassen
Christopher Clark
Elisa Conti
Anaïs Corma-Gómez
Emanuele Costantini
Carlo Custodero
Delphine Daian
Maria Carolina Dalmasso
Antonio Daniele
Efthimios Dardiotis
Jean-François Dartigues
Peter Paul de Deyn
Katia de Paiva Lopes
Lot D de Witte
Stéphanie Debette
Jürgen Deckert
Teodoro Del Ser
Nicola Denning
Anita DeStefano
Martin Dichgans
Janine Diehl-Schmid
Mónica Diez-Fairen
Paolo Dionigi Rossi
Srdjan Djurovic
Emmanuelle Duron
Emrah Düzel
Carole Dufouil
Gudny Eiriksdottir
Sebastiaan Engelborghs
Valentina Escott-Price
Ana Espinosa
Michael Ewers
Kelley M Faber
Tagliavini Fabrizio
Sune Fallgaard Nielsen
David W Fardo
Lucia Farotti
Chiara Fenoglio
Marta Fernández-Fuertes
Raffaele Ferrari
Catarina B Ferreira
Evelyn Ferri
Bertrand Fin
Peter Fischer
Tormod Fladby
Klaus Fließbach
Bernard Fongang
Myriam Fornage
Juan Fortea
Tatiana M Foroud
Silvia Fostinelli
Nick C Fox
Emlio Franco-Macías
María J Bullido
Ana Frank-García
Lutz Froelich
Brian Fulton-Howard
Daniela Galimberti
Jose Maria García-Alberca
Pablo García-González
Sebastian Garcia-Madrona
Guillermo Garcia-Ribas
Roberta Ghidoni
Ina Giegling
Giaccone Giorgio
Alison M Goate
Oliver Goldhardt
Duber Gomez-Fonseca
Antonio González-Pérez
Caroline Graff
Giulia Grande
Emma Green
Timo Grimmer
Edna Grünblatt
Michelle Grunin
Vilmundur Gudnason
Tamar Guetta-Baranes
Annakaisa Haapasalo
Georgios Hadjigeorgiou
Jonathan L Haines
Kara L Hamilton-Nelson
Harald Hampel
Olivier Hanon
John Hardy
Annette M Hartmann
Lucrezia Hausner
Janet Harwood
Stefanie Heilmann-Heimbach
Seppo Helisalmi
Michael T Heneka
Isabel Hernández
Martin J Herrmann
Per Hoffmann
Clive Holmes
Henne Holstege
Raquel Huerto Vilas
Marc Hulsman
Jack Humphrey
Geert Jan Biessels
Xueqiu Jian
Charlotte Johansson
Gyungah R Jun
Yuriko Kastumata
John Kauwe
Patrick G Kehoe
Lena Kilander
Anne Kinhult Ståhlbom
Miia Kivipelto
Anne Koivisto
Johannes Kornhuber
Mary H Kosmidis
Walter A Kukull
Pavel P Kuksa
Brian W Kunkle
Amanda B Kuzma
Carmen Lage
Erika J Laukka
Lenore Launer
Alessandra Lauria
Chien-Yueh Lee
Jenni Lehtisalo
Ondrej Lerch
Alberto Lleó
William Longstreth
Oscar Lopez
Adolfo Lopez de Munain
Seth Love
Malin Löwemark
Lauren Luckcuck
Kathryn L Lunetta
Yiyi Ma
Juan Macías
Catherine A MacLeod
Wolfgang Maier
Francesca Mangialasche
Marco Spallazzi
Marta Marquié
Rachel Marshall
Eden R Martin
Angel Martín Montes
Carmen Martínez Rodríguez
Carlo Masullo
Richard Mayeux
Simon Mead
Patrizia Mecocci
Miguel Medina
Alun Meggy
Shima Mehrabian
Silvia Mendoza
Manuel Menéndez-González
Pablo Mir
Susanne Moebus
Merel Mol
Laura Molina-Porcel
Laura Montrreal
Laura Morelli
Fermin Moreno
Kevin Morgan
Thomas Mosley
Markus M Nöthen
Carolina Muchnik
Shubhabrata Mukherjee
Benedetta Nacmias
Tiia Ngandu
Gael Nicolas
Børge G Nordestgaard
Robert Olaso
Adelina Orellana
Michela Orsini
Gemma Ortega
Alessandro Padovani
Caffarra Paolo
Goran Papenberg
Lucilla Parnetti
Florence Pasquier
Pau Pastor
Gina Peloso
Alba Pérez-Cordón
Jordi Pérez-Tur
Pierre Pericard
Oliver Peters
Yolande A L Pijnenburg
Juan A Pineda
Gerard Piñol-Ripoll
Claudia Pisanu
Thomas Polak
Julius Popp
Danielle Posthuma
Josef Priller
Raquel Puerta
Olivier Quenez
Inés Quintela
Jesper Qvist Thomassen
Alberto Rábano
Innocenzo Rainero
Farid Rajabli
Inez Ramakers
Luis M Real
Marcel J T Reinders
Christiane Reitz
Dolly Reyes-Dumeyer
Perry Ridge
Steffi Riedel-Heller
Peter Riederer
Natalia Roberto
Eloy Rodriguez-Rodriguez
Arvid Rongve
Irene Rosas Allende
Maitée Rosende-Roca
Jose Luis Royo
Elisa Rubino
Dan Rujescu
María Eugenia Sáez
Paraskevi Sakka
Ingvild Saltvedt
Ángela Sanabria
María Bernal Sánchez-Arjona
Florentino Sanchez-Garcia
Pascual Sánchez Juan
Raquel Sánchez-Valle
Sigrid B Sando
Chloé Sarnowski
Claudia L Satizabal
Michela Scamosci
Nikolaos Scarmeas
Elio Scarpini
Philip Scheltens
Norbert Scherbaum
Martin Scherer
Matthias Schmid
Anja Schneider
Jonathan M Schott
Geir Selbæk
Davide Seripa
Manuel Serrano
Jin Sha
Alexey A Shadrin
Olivia Skrobot
Susan Slifer
Gijsje J L Snijders
Hilkka Soininen
Vincenzo Solfrizzi
Alina Solomon
Yeunjoo Song
Sandro Sorbi
Oscar Sotolongo-Grau
Gianfranco Spalletta
Annika Spottke
Alessio Squassina
Eystein Stordal
Juan Pablo Tartan
Lluís Tárraga
Niccolo Tesí
Anbupalam Thalamuthu
Tegos Thomas
Giuseppe Tosto
Latchezar Traykov
Lucio Tremolizzo
Anne Tybjærg-Hansen
Andre Uitterlinden
Abbe Ullgren
Ingun Ulstein
Sergi Valero
Otto Valladares
Christine Van Broeckhoven
Jeffery Vance
Badri N Vardarajan
Aad van der Lugt
Jasper Van Dongen
Jeroen van Rooij
John van Swieten
Rik Vandenberghe
Frans Verhey
Jean-Sébastien Vidal
Jonathan Vogelgsang
Martin Vyhnalek
Michael Wagner
David Wallon
Li-San Wang
Ruiqi Wang
Leonie Weinhold
Jens Wiltfang
Gill Windle
Bob Woods
Mary Yannakoulia
Habil Zare
Yi Zhao
Xiaoling Zhang
Congcong Zhu
Miren Zulaica
Lindsay A Farrer
Bruce M Psaty
Mohsen Ghanbari
Towfique Raj
Perminder Sachdev
Karen Mather
Frank Jessen
M Arfan Ikram
Alexandre de Mendonça
Jakub Hort
Magda Tsolaki
Margaret A Pericak-Vance
Philippe Amouyel
Julie Williams
Ruth Frikke-Schmidt
Jordi Clarimon
Jean-François Deleuze
Giacomina Rossi
Sudha Seshadri
Ole A Andreassen
Martin Ingelsson
Mikko Hiltunen
Kristel Sleegers
Gerard D Schellenberg
Cornelia M van Duijn
Rebecca Sims
Wiesje M van der Flier
Agustín Ruiz
Alfredo Ramirez
Jean-Charles Lambert

Publication Date

4-1-2022

Journal

National Genetics

Abstract

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.

Keywords

Alzheimer Disease, Cognitive Dysfunction, Genome-Wide Association Study, Humans, tau Proteins

Included in

Public Health Commons

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