Journal Articles

Publication Date



Journal of the American Heart Association


BACKGROUND: Brain arterial diameters (BADs) are novel imaging biomarkers of cerebrovascular disease, cognitive decline, and dementia. Traditional vascular risk factors have been associated with BADs, but whether there may be genetic determinants of BADs is unknown.

METHODS AND RESULTS: The authors studied 4150 participants from 6 geographically diverse population-based cohorts (40% European, 14% African, 22% Hispanic, 24% Asian ancestries). Brain arterial diameters for 13 segments were measured and averaged to obtain a global measure of BADs as well as the posterior and anterior circulations. A genome-wide association study revealed 14 variants at one locus associated with global BAD at genome-wide significance (

CONCLUSIONS: The current study reveals 3 novel risk loci (


Humans, Brain, Genetic Predisposition to Disease, Genome-Wide Association Study, Methyltransferases, Polymorphism, Single Nucleotide, Chromosomes, Human, Pair 10



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