Student and Faculty Publications
Publication Date
8-1-2021
Journal
The FEBS Journal
Abstract
UNLABELLED: We investigated the mechanisms associated with E22K mutation in myosin regulatory light chain (RLC), found to cause hypertrophic cardiomyopathy (HCM) in humans and mice. Specifically, we characterized the mechanical profiles of papillary muscle fibers from transgenic mice expressing human ventricular RLC wild-type (Tg-WT) or E22K mutation (Tg-E22K). Because the two mouse models expressed different amounts of transgene, the B6SJL mouse line (NTg) was used as an additional control. Mechanical experiments were carried out on Ca
SUB-DISCIPLINE: Bioenergetics.
DATABASE: The data that support the findings of this study are available from the corresponding authors upon reasonable request.
ANIMAL PROTOCOL: BK20150353 (Soochow University).
RESEARCH GOVERNANCE: School of Nursing: Hua-Gang Hu: seuboyh@163.com; Soochow University: Chen Ge chge@suda.edu.cn.
Keywords
Adenosine Triphosphate, Animals, Biomechanical Phenomena, Calcium, Cardiomyopathy, Hypertrophic, Elasticity, Female, Male, Mice, Mutation, Missense, Myocardial Contraction, Myofibrils, Myosin Light Chains