Faculty, Staff and Student Publications
Publication Date
7-1-2023
Journal
Research in Autism Spectrum Disorders
Abstract
BACKGROUND: Comorbidity of eczema with autism spectrum disorder (ASD) is increasing. We investigated the associations of eczema and its possible interaction with polymorphisms in glutathione S-transferase (GST) genes in relation to ASD and ASD severity.
METHOD: Using data from 344 1:1 age- and sex-matched ASD cases and typically developing controls, we assessed additive and interactive associations of eczema with GST genes in relation to ASD by applying conditional logistic regression models, and in relation to ASD severity in ASD cases as measured by the Autism Diagnostic Observation Schedule-2nd Edition (ADOS-2) total and domain-specific comparison scores (CSs) by fitting general linear models.
RESULTS: After adjusting for child's age and history of breastfeeding, eczema had no additive association with ASD [Matched Odds ratio (MOR) and 95% Confidence Intervals (CI): 1.04 (0.76, 1.41),
CONCLUSION: Our findings suggest children with certain genotypes for GST genes may be more susceptible for comorbidity of eczema and ASD, which is consistent with the role of GST genes in both conditions.
Keywords
Autism Spectrum Disorder, Eczema, Glutathione S-transferase, Oxidative Stress, Interaction, Comorbidity
DOI
10.1016/j.rasd.2023.102183
PMID
40051779
PMCID
PMC11884259
PubMedCentral® Posted Date
3-6-2025
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes