Faculty, Staff and Student Publications
Publication Date
2-28-2024
Journal
Nature Communications
Abstract
Sleep-disordered breathing (SDB) is a prevalent disorder characterized by recurrent episodic upper airway obstruction. Using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we apply principal component analysis (PCA) to seven SDB-related measures. We estimate the associations of the top two SDB PCs with serum levels of 617 metabolites, in both single-metabolite analysis, and a joint penalized regression analysis. The discovery analysis includes 3299 individuals, with validation in a separate dataset of 1522 individuals. Five metabolite associations with SDB PCs are discovered and replicated. SDB PC1, characterized by frequent respiratory events common in older and male adults, is associated with pregnanolone and progesterone-related sulfated metabolites. SDB PC2, characterized by short respiratory event length and self-reported restless sleep, enriched in young adults, is associated with sphingomyelins. Metabolite risk scores (MRSs), representing metabolite signatures associated with the two SDB PCs, are associated with 6-year incident hypertension and diabetes. These MRSs have the potential to serve as biomarkers for SDB, guiding risk stratification and treatment decisions.
Keywords
Young Adult, Humans, Male, Aged, Sleep Apnea Syndromes, Diabetes Mellitus, Hypertension, Risk Factors, Regression Analysis
DOI
10.1038/s41467-024-46019-y
PMID
38418471
PMCID
PMC10902315
PubMedCentral® Posted Date
2-28-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes