Mendelian Randomization Supports Bidirectional Causality Between Telomere Length and Clonal Hematopoiesis of Indeterminate Potential

Authors

Tetsushi Nakao
Alexander G Bick
Margaret A Taub
Seyedeh M Zekavat
Md M Uddin
Abhishek Niroula
Cara L Carty
John Lane
Michael C Honigberg
Joshua S Weinstock
Akhil Pampana
Christopher J Gibson
Gabriel K Griffin
Shoa L Clarke
Romit Bhattacharya
Themistocles L Assimes
Leslie S Emery
Adrienne M Stilp
Quenna Wong
Jai Broome
Cecelia A Laurie
Alyna T Khan
Albert V Smith
Thomas W Blackwell
Veryan Codd
Christopher P Nelson
Zachary T Yoneda
Juan M Peralta
Donald W Bowden
Marguerite R Irvin
Meher Boorgula
Wei Zhao
Lisa R Yanek
Kerri L Wiggins
James E Hixson
C Charles Gu
Gina M Peloso
Dan M Roden
Muagututi'a S Reupena
Chii-Min Hwu
Dawn L DeMeo
Kari E North
Shannon Kelly
Solomon K Musani
Joshua C Bis
Donald M Lloyd-Jones
Jill M Johnsen
Michael Preuss
Russell P Tracy
Patricia A Peyser
Dandi Qiao
Pinkal Desai
Joanne E Curran
Barry I Freedman
Hemant K Tiwari
Sameer Chavan
Jennifer A Smith
Nicholas L Smith
Tanika N Kelly
Bertha Hidalgo
L Adrienne Cupples
Daniel E Weeks
Nicola L Hawley
Ryan L Minster
Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group
Ranjan Deka
Take T Naseri
Lisa de las Fuentes
Laura M Raffield
Alanna C Morrison
Paul S Vries
Christie M Ballantyne
Eimear E Kenny
Stephen S Rich
Eric A Whitsel
Michael H Cho
M Benjamin Shoemaker
Betty S Pace
John Blangero
Nicholette D Palmer
Braxton D Mitchell
Alan R Shuldiner
Kathleen C Barnes
Susan Redline
Sharon L R Kardia
Gonçalo R Abecasis
Lewis C Becker
Susan R Heckbert
Jiang He
Wendy Post
Donna K Arnett
Ramachandran S Vasan
Dawood Darbar
Scott T Weiss
Stephen T McGarvey
Mariza de Andrade
Yii-Der Ida Chen
Robert C Kaplan
Deborah A Meyers
Brian S Custer
Adolfo Correa
Bruce M Psaty
Myriam Fornage
JoAnn E Manson
Eric Boerwinkle
Barbara A Konkle
Ruth J F Loos
Jerome I Rotter
Edwin K Silverman
Charles Kooperberg
John Danesh
Nilesh J Samani
Siddhartha Jaiswal
Peter Libby
Patrick T Ellinor
Nathan Pankratz
Benjamin L Ebert
Alexander P Reiner
Rasika A Mathias
Ron Do
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Pradeep Natarajan

Publication Date

4-8-2022

Journal

Science Advances

Abstract

Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by expansion of hematopoietic cells bearing leukemogenic mutations, predisposes both hematologic malignancy and CAD.

DOI

10.1126/sciadv.abl6579

PMID

35385311

PMCID

PMC8986098

PubMedCentral® Posted Date

4-6-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes