Faculty, Staff and Student Publications
Publication Date
3-29-2023
Journal
Scientific Reports
Abstract
APOE-ɛ4 risk on Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) differs between race/ethnic groups, presumably due to ancestral genomic background surrounding the APOE locus. We studied whether African and Amerindian ancestry-enriched genetic variants in the APOE region modify the effect of the APOE-ɛ4 alleles on Mild Cognitive Impairment (MCI) in Hispanics/Latinos. We defined African and Amerindian ancestry-enriched variants as those common in one Hispanic/Latino parental ancestry and rare in the other two. We identified such variants in the APOE region with a predicted moderate impact based on the SnpEff tool. We tested their interaction with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) population and African Americans from the Atherosclerosis Risk In Communities (ARIC) study. We identified 5 Amerindian and 14 African enriched variants with an expected moderate effect. A suggestive significant interaction (p-value = 0.01) was found for one African-enriched variant, rs8112679, located in the ZNF222 gene fourth exon. Our results suggest there are no ancestry-enriched variants with large effect sizes of interaction effects with APOE-ɛ4 on MCI in the APOE region in the Hispanic/Latino population. Further studies are needed in larger datasets to identify potential interactions with smaller effect sizes.
Keywords
Humans, Aging, Alzheimer Disease, Apolipoprotein E4, Cognitive Dysfunction, Hispanic or Latino
DOI
10.1038/s41598-023-32028-2
PMID
36991100
PMCID
PMC10060219
PubMedCentral® Posted Date
3-29-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Medical Genetics Commons, Medicine and Health Commons, Neurosciences Commons, Public Health Commons, Race and Ethnicity Commons