Faculty, Staff and Student Publications
Publication Date
1-1-2023
Journal
EBioMedicine
Abstract
BACKGROUND: Sleep phenotypes have been reported to be associated with cognitive ageing outcomes. However, there is limited research using genetic variants as proxies for sleep traits to study their associations. We estimated associations between Polygenic Risk Scores (PRSs) for sleep duration, insomnia, daytime sleepiness, and obstructive sleep apnoea (OSA) and measures of cogntive ageing in Hispanic/Latino adults.
METHODS: We used summary statistics from published genome-wide association studies to construct PRSs representing the genetic basis of each sleep trait, then we studied the association of the PRSs of the sleep phenotypes with cognitive outcomes in the Hispanic Community Healthy Study/Study of Latinos. The primary model adjusted for age, sex, study centre, and measures of genetic ancestry. Associations are highlighted if their p-value <0.05.
FINDINGS: Higher PRS for insomnia was associated with lower global cognitive function and higher risk of mild cognitive impairment (MCI) (OR = 1.20, 95% CI [1.06, 1.36]). Higher PRS for daytime sleepiness was also associated with increased MCI risk (OR = 1.14, 95% CI [1.02, 1.28]). Sleep duration PRS was associated with reduced MCI risk among short and normal sleepers, while among long sleepers it was associated with reduced global cognitive function and with increased MCI risk (OR = 1.40, 95% CI [1.10, 1.78]). Furthermore, adjustment of analyses for the measured sleep phenotypes and APOE-ε4 allele had minor effects on the PRS associations with the cognitive outcomes.
INTERPRETATION: Genetic measures underlying insomnia, daytime sleepiness, and sleep duration are associated with MCI risk. Genetic and self-reported sleep duration interact in their effect on MCI.
FUNDING: Described in Acknowledgments.
Keywords
Humans, Sleep Initiation and Maintenance Disorders, Genome-Wide Association Study, Sleep, Cognitive Dysfunction, Disorders of Excessive Somnolence, Self Report, Cognition, Hispanic or Latino, Aging, Global cognitive function, Mild cognitive impairment, Sleep duration, Insomnia, Daytime sleepiness, Polygenetic risk score
DOI
10.1016/j.ebiom.2022.104393
PMID
36493726
PMCID
PMC9732133
PubMedCentral® Posted Date
12-6-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Community Health and Preventive Medicine Commons, Public Health Education and Promotion Commons, Race and Ethnicity Commons