Student and Faculty Publications

Authors

Jari Lahti
Samuli Tuominen
Qiong Yang
Giulio Pergola
Shahzad Ahmad
Najaf Amin
Nicola J Armstrong
Alexa Beiser
Katharina Bey
Joshua C Bis
Eric Boerwinkle
Jan Bressler
Archie Campbell
Harry Campbell
Qiang Chen
Janie Corley
Simon R Cox
Gail Davies
Philip L De Jager
Eske M Derks
Jessica D Faul
Annette L Fitzpatrick
Alison E Fohner
Ian Ford
Myriam Fornage
Zachary Gerring
Hans J Grabe
Francine Grodstein
Vilmundur Gudnason
Eleanor Simonsick
Elizabeth G Holliday
Peter K Joshi
Eero Kajantie
Jaakko Kaprio
Pauliina Karell
Luca Kleineidam
Maria J Knol
Nicole A Kochan
John B Kwok
Markus Leber
Max Lam
Teresa Lee
Shuo Li
Anu Loukola
Tobias Luck
Riccardo E Marioni
Karen A Mather
Sarah Medland
Saira S Mirza
Mike A Nalls
Kwangsik Nho
Adrienne O'Donnell
Christopher Oldmeadow
Jodie Painter
Alison Pattie
Simone Reppermund
Shannon L Risacher
Richard J Rose
Vijay Sadashivaiah
Markus Scholz
Claudia L Satizabal
Peter W Schofield
Katharina E Schraut
Rodney J Scott
Jeannette Simino
Albert V Smith
Jennifer A Smith
David J Stott
Ida Surakka
Alexander Teumer
Anbupalam Thalamuthu
Stella Trompet
Stephen T Turner
Sven J van der Lee
Arno Villringer
Uwe Völker
Robert S Wilson
Katharina Wittfeld
Eero Vuoksimaa
Rui Xia
Kristine Yaffe
Lei Yu
Habil Zare
Wei Zhao
David Ames
John Attia
David A Bennett
Henry Brodaty
Daniel I Chasman
Aaron L Goldman
Caroline Hayward
M Arfan Ikram
J Wouter Jukema
Sharon L R Kardia
Todd Lencz
Markus Loeffler
Venkata S Mattay
Aarno Palotie
Bruce M Psaty
Alfredo Ramirez
Paul M Ridker
Steffi G Riedel-Heller
Perminder S Sachdev
Andrew J Saykin
Martin Scherer
Peter R Schofield
Stephen Sidney
John M Starr
Julian Trollor
William Ulrich
Michael Wagner
David R Weir
James F Wilson
Margaret J Wright
Daniel R Weinberger
Stephanie Debette
Johan G Eriksson
Thomas H Mosley
Lenore J Launer
Cornelia M van Duijn
Ian J Deary
Sudha Seshadri
Katri Räikkönen

Publication Date

11-1-2022

Journal

Nature Portfolio

Abstract

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.

Keywords

Memory, Short-Term, Learning, Verbal Learning, Multifactorial Inheritance, Brain

Included in

Public Health Commons

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