A Mendelian Randomization Study of Genetic Liability to Post-traumatic Stress Disorder and Risk of Ischemic Stroke

Authors

Opeyemi Soremekun
Clarisse Musanabaganwa
Annette Uwineza
Maddalena Ardissino
Skanda Rajasundaram
Agaz H Wani
Stefan Jansen
Jean Mutabaruka
Eugene Rutembesa
Chisom Soremekun
Cisse Cheickna
Mamadou Wele
Joseph Mugisha
Oyekanmi Nash
Eugene Kinyanda
Dorothea Nitsch
Myriam Fornage
Tinashe Chikowore
Dipender Gill
Derek E Wildman
Leon Mutesa
Monica Uddin
Segun Fatumo

Publication Date

7-1-2023

Journal

Translational Psychiatry

Abstract

Observational studies have shown an association between post-traumatic stress disorder (PTSD) and ischemic stroke (IS) but given the susceptibility to confounding it is unclear if these associations represent causal effects. Mendelian randomization (MR) facilitates causal inference that is robust to the influence of confounding. Using two sample MR, we investigated the causal effect of genetic liability to PTSD on IS risk. Ancestry-specific genetic instruments of PTSD and four quantitative sub-phenotypes of PTSD, including hyperarousal, avoidance, re-experiencing, and total symptom severity score (PCL-Total) were obtained from the Million Veteran Programme (MVP) using a threshold P value (P) of <5 >× 10

Keywords

Humans, Ischemic Stroke, Stress Disorders, Post-Traumatic, Genome-Wide Association Study, Mendelian Randomization Analysis, Stroke

DOI

10.1038/s41398-023-02542-y

PMID

37391434

PMCID

PMC10313806

PubMedCentral® Posted Date

7-1-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes