Faculty, Staff and Student Publications
Publication Date
6-1-2023
Journal
Cancer Epidemiology, Biomarkers & Prevention
Abstract
BACKGROUND: Literature on colorectal cancer outcomes in individuals of Middle Eastern and North African (MENA) descent is limited. To address this gap, we estimated five-year colorectal cancer-specific survival by race and ethnicity, including MENA individuals, in a diverse, population-based sample in California.
METHODS: We identified adults (ages 18-79 years) diagnosed with a first or only colorectal cancer in 2004 to 2017 using the California Cancer Registry (CCR), including non-Hispanic White, non-Hispanic Black, non-Hispanic Asian, Hispanic, and MENA individuals. For each racial/ethnic group, we calculated five-year colorectal cancer-specific survival and used Cox proportional hazards regression models to examine the association of race/ethnicity and survival, adjusting for clinical and socio demographic factors.
RESULTS: Of 110,192 persons diagnosed with colorectal cancer, five-year colorectal cancer-specific survival was lowest in Black (61.0%) and highest in MENA (73.2%) individuals. Asian (72.2%) individuals had higher survival than White (70.0%) and Hispanic (68.2%) individuals. In adjusted analysis, MENA [adjusted HR (aHR), 0.82; 95% confidence interval (CI), 0.76-0.89], Asian (aHR, 0.86; 95% CI, 0.83-0.90), and Hispanic (aHR, 0.94; 95% CI, 0.91-0.97) race/ethnicity were associated with higher, and Black (aHR, 1.13; 95% CI, 1.09-1.18) race/ethnicity was associated with lower survival compared with non-Hispanic White race/ethnicity.
CONCLUSIONS: To our knowledge, this is the first study to report colorectal cancer survival in MENA individuals in the United States. We observed higher survival of MENA individuals compared with other racial/ethnic groups, adjusting for sociodemographic and clinical factors.
IMPACT: Future studies are needed to identify factors contributing to cancer outcomes in this unique population.
Keywords
Adult, Humans, California, Colorectal Neoplasms, North African People, United States, White, Adolescent, Young Adult, Middle Aged, Aged, Middle Eastern People
DOI
10.1158/1055-9965.EPI-22-1326
PMID
37012208
PMCID
PMC11338047
PubMedCentral® Posted Date
8-21-2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Gastroenterology Commons, Oncology Commons, Place and Environment Commons, Public Health Commons