Language
English
Publication Date
2-1-2016
Journal
Curr Opin Neurobiol
DOI
10.1016/j.conb.2015.10.007
PMID
26517286
PMCID
PMC4738159
PubMedCentral® Posted Date
2-1-2017
PubMedCentral® Full Text Version
Author MSS
Abstract
The discovery of over 150 monogenic epilepsies and advances in early genetic diagnoses have launched a search for molecular strategies and developmental timetables to reverse or even prevent the course of these debilitating brain disorders. Orthologous rodent models of key disease genes are providing important examples of the range of targets, and serve as valuable test systems for perinatal therapeutic approaches. While gene-specific analyses of single rare 'orphan' diseases are each narrow in scope, they illuminate downstream pathways converging onto interneurons, and treatments that strengthen inhibition during cortical maturation may provide broad protection against these seemingly disparate gene errors. Several genes, even those linked to malformations, show promise for postnatal correction before the onset of their clinical phenotype.
Published Open-Access
yes
Recommended Citation
, "Early rescue of interneuron disease trajectory in developmental epilepsies" (2016). Faculty, Staff and Students Publications. 24.
https://digitalcommons.library.tmc.edu/baylor_docs/24