Early rescue of interneuron disease trajectory in developmental epilepsies

Authors

MS Siehr, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX
JL Noebels, Department of Molecular and Human Genetics, Department of Neurology, Department of Neuroscience, Baylor College of Medicine, Houston, TX

Publication Date

2-1-2016

Journal

Curr Opin Neurobiol

DOI

10.1016/j.conb.2015.10.007

PMID

26517286

PMCID

PMC4738159

PubMedCentral® Posted Date

2-1-2017

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

no

Abstract

The discovery of over 150 monogenic epilepsies and advances in early genetic diagnoses have launched a search for molecular strategies and developmental timetables to reverse or even prevent the course of these debilitating brain disorders. Orthologous rodent models of key disease genes are providing important examples of the range of targets, and serve as valuable test systems for perinatal therapeutic approaches. While gene-specific analyses of single rare 'orphan' diseases are each narrow in scope, they illuminate downstream pathways converging onto interneurons, and treatments that strengthen inhibition during cortical maturation may provide broad protection against these seemingly disparate gene errors. Several genes, even those linked to malformations, show promise for postnatal correction before the onset of their clinical phenotype.