Language
English
Publication Date
1-1-2024
Journal
Drug Discovery Today
DOI
10.1016/j.drudis.2023.103832
PMID
37977285
PMCID
PMC10872262
PubMedCentral® Posted Date
1-1-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
As a highly contagious human pathogen, severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) has infected billions of people worldwide with more than 6 million deaths. With several effective vaccines and antiviral drugs now available, the SARS-CoV-2 pandemic been brought under control. However, a new pathogenic coronavirus could emerge in the future, given the zoonotic nature of this virus. Natural evolution and drug-induced mutations of SARS-CoV-2 also require continued efforts for new anti-coronavirus drugs. Nonstructural protein (nsp) 3 of CoVs is a large, multifunctional protein, containing a papain-like protease (PLpro) and a macrodomain (Mac1), which are essential for viral replication. Here, we provide a comprehensive review of the function, structure, and inhibition of SARS-CoV/-CoV-2 PLpro and Mac1. We also discuss advances in, and challenges to, the discovery of drugs against these targets.
Keywords
Humans, SARS-CoV-2, COVID-19, Antiviral Agents, Virus Replication, Drug Discovery, SARS-CoV-2, Papain-like protease, Macrodomain, Inhibitors, Drug discovery
Published Open-Access
yes
Recommended Citation
, "Targeting SARS-CoV-2 Nonstructural Protein 3: Function, Structure, Inhibition, and Perspective in Drug Discovery" (2024). Faculty, Staff and Students Publications. 3864.
https://digitalcommons.library.tmc.edu/baylor_docs/3864