Language
English
Publication Date
1-1-2021
Journal
Nephron
DOI
10.1159/000515422
PMID
33853077
PMCID
PMC8266727
PubMedCentral® Posted Date
4-14-2022
PubMedCentral® Full Text Version
Author MSS
Abstract
Recent advances in large-scale RNA sequencing and genome-wide profiling projects have unraveled a heterogeneous group of RNAs, collectively known as long noncoding RNAs (lncRNAs), which play central roles in many diverse biological processes. Importantly, an association between aberrant expression of lncRNAs and diverse human pathologies has been reported, including in a variety of kidney diseases. These observations have raised the possibility that lncRNAs may represent unexploited potential therapeutic targets for kidney diseases. Several important questions regarding the functionality of lncRNAs and their impact in kidney diseases, however, remain to be carefully addressed. Here, we provide an overview of the main functions and mechanisms of actions of lncRNAs, and their promise as therapeutic targets in kidney diseases, emphasizing on the role of some of the best-characterized lncRNAs implicated in the pathogenesis and progression of diabetic nephropathy.
Keywords
Diabetic Nephropathies, Humans, Kidney, RNA, Long Noncoding, RNA, non-coding RNA, lncRNA, Kidneys, Diabetic Nephropathy
Published Open-Access
yes
Recommended Citation
, "Long Noncoding RNAs and Their Therapeutic Promise in Diabetic Nephropathy" (2021). Faculty, Staff and Students Publications. 416.
https://digitalcommons.library.tmc.edu/baylor_docs/416