Long Noncoding RNAs and Their Therapeutic Promise in Diabetic Nephropathy

Authors

Juan D Coellar
Jianyin Long
Farhad R Danesh

Language

English

Publication Date

1-1-2021

Journal

Nephron

DOI

10.1159/000515422

PMID

33853077

PMCID

PMC8266727

PubMedCentral® Posted Date

4-14-2022

PubMedCentral® Full Text Version

Author MSS

Abstract

Recent advances in large-scale RNA sequencing and genome-wide profiling projects have unraveled a heterogeneous group of RNAs, collectively known as long noncoding RNAs (lncRNAs), which play central roles in many diverse biological processes. Importantly, an association between aberrant expression of lncRNAs and diverse human pathologies has been reported, including in a variety of kidney diseases. These observations have raised the possibility that lncRNAs may represent unexploited potential therapeutic targets for kidney diseases. Several important questions regarding the functionality of lncRNAs and their impact in kidney diseases, however, remain to be carefully addressed. Here, we provide an overview of the main functions and mechanisms of actions of lncRNAs, and their promise as therapeutic targets in kidney diseases, emphasizing on the role of some of the best-characterized lncRNAs implicated in the pathogenesis and progression of diabetic nephropathy.

Keywords

Diabetic Nephropathies, Humans, Kidney, RNA, Long Noncoding, RNA, non-coding RNA, lncRNA, Kidneys, Diabetic Nephropathy

Published Open-Access

yes

Recommended Citation

Juan D Coellar, Jianyin Long, and Farhad R Danesh, "Long Noncoding RNAs and Their Therapeutic Promise in Diabetic Nephropathy" (2021). Faculty and Staff Publications. 416.
https://digitalcommons.library.tmc.edu/baylor_docs/416