Language
English
Publication Date
10-16-2023
Journal
The EMBO Journal
DOI
10.15252/embj.2023115307
PMID
37691515
PMCID
PMC10577535
PubMedCentral® Posted Date
9-11-2023
PubMedCentral® Full Text Version
Post-print
Abstract
Removal of polyploid cells is essential to preventing cancer and restricting tumor growth. A new study published in The EMBO Journal shows assembly of the NEMO-PIDDosome on extra centrioles. Activation of this protein complex leads to NF-κB activation that, in turn, induces NK cell-mediated cell clearance.
Keywords
Humans, Gene Expression Regulation, I-kappa B Kinase, Killer Cells, Natural, NF-kappa B, Polyploidy, Signal Transduction, Cancer, Cell Cycle, Immunology
Published Open-Access
yes
Recommended Citation
, "Got PIDD1? Natural Killer Cells Clear Polyploid Cells To Ensure a Balanced Genome" (2023). Faculty, Staff and Students Publications. 4909.
https://digitalcommons.library.tmc.edu/baylor_docs/4909