Got PIDD1? Natural Killer Cells Clear Polyploid Cells To Ensure a Balanced Genome

Authors

Alexandra N Brown-Suedel
Lisa Bouchier-Hayes

Language

English

Publication Date

10-16-2023

Journal

The EMBO Journal

DOI

10.15252/embj.2023115307

PMID

37691515

PMCID

PMC10577535

PubMedCentral® Posted Date

9-11-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Removal of polyploid cells is essential to preventing cancer and restricting tumor growth. A new study published in The EMBO Journal shows assembly of the NEMO-PIDDosome on extra centrioles. Activation of this protein complex leads to NF-κB activation that, in turn, induces NK cell-mediated cell clearance.

Keywords

Humans, Gene Expression Regulation, I-kappa B Kinase, Killer Cells, Natural, NF-kappa B, Polyploidy, Signal Transduction, Cancer, Cell Cycle, Immunology

Published Open-Access

yes

Recommended Citation

Alexandra N Brown-Suedel and Lisa Bouchier-Hayes, "Got PIDD1? Natural Killer Cells Clear Polyploid Cells To Ensure a Balanced Genome" (2023). Faculty and Staff Publications. 4909.
https://digitalcommons.library.tmc.edu/baylor_docs/4909