An Integrated Cardiometabolic Genetic Testing Program in a Predominantly Hispanic Population Within a Community Setting

Authors

• Bo Yuan
• Layla A Abushamat
• Stacey Pereira
• Surya Narayan Mulukutla
• Grace E Tietz
• Eric Venner
• Sara E Kalla
• Breanna Lee
• Donna Muzny
• Ginger Metcalf
• Mullai Murugan
• Sarah H Elsea
• Senkottuvelan Kadirvel
• Lele Li
• Joshi Stephen
• Shengfeng Xu
• Victoria Yi
• Monica Sulit
• Christie L Kovar
• Kimberly Walker
• Marie-Claude Gingras
• Jianhong Hu
• Fei Yan
• Taeko Gerber
• Viktoriya Korchina
• C Michael Fordis
• Ruchi Gaba
• Mahesh Changlani
• Herschl Silberman
• Hadley Stevens Smith
• Christine M Eng
• Jennifer E Posey
• Clarisa Medina
• Lisa R Treviño
• Christie M Ballantyne
• Richard A Gibbs
• Ashok Balasubramanyam

Language

English

Publication Date

7-1-2026

Journal

Genetics in Medicine

DOI

10.1016/j.gim.2026.102595

PMID

42104850

PMCID

PMC13430617

PubMedCentral® Posted Date

8-4-2026

PubMedCentral® Full Text Version

Author MSS

Abstract

Purpose: This study aimed to apply cardiometabolic genetic testing in a community setting with a predominantly Hispanic population and assess feasibility and perspectives toward genetic testing.

Methods: A genome-sequencing-based genetic panel for cardiometabolic disorders (177 genes related to monogenic conditions, 2 LPA risk alleles, 2 pharmacogenomic loci, and ancestry-adjusted polygenic risk scores for type 2 diabetes and coronary artery disease) was deployed in community cardiology and endocrinology clinics in South Texas. A survey on perceptions toward genetic testing was administered after return of results.

Results: Testing was completed for 776 patients (18-92 years old, 92% Hispanic). 26 patients (3.4%) were identified with a pathogenic or likely pathogenic variant in a monogenic disease gene, including 17 diagnostic and 9 secondary findings. Additionally, 291 (37.5%), 181 (23.3%), and 298 (38.4%) patients were identified with at least 1 LPA risk allele, pharmacogenomic finding, or elevated polygenic risk scores, respectively. Patients perceived the testing to be beneficial with few concerns.

Conclusion: This study expanded cardiometabolic genetic testing to a predominantly Hispanic population in a community setting, providing actionable guidance for disease diagnosis, intervention, and preventive care with a favorable patient perception.

Keywords

Humans, Female, Hispanic or Latino, Middle Aged, Adult, Male, Genetic Testing, Aged, Adolescent, Genetic Risk Score, Aged, 80 and over, Young Adult, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Texas, Genetic Predisposition to Disease, Alleles, Coronary Artery Disease, Cardiometabolic disorders, community-based genetic testing, Hispanic population

Published Open-Access

yes

Recommended Citation

Yuan, Bo; Abushamat, Layla A; Pereira, Stacey; et al., "An Integrated Cardiometabolic Genetic Testing Program in a Predominantly Hispanic Population Within a Community Setting" (2026). Center for Medical Ethics and Health Policy Staff Publications. 386.
https://digitalcommons.library.tmc.edu/med_ethics/386